Title

Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

Author

EDUARDO PLATA VARGAS

Cinthia Yareli De la Cruz Hernández

ALEJANDRO DORAZCO GONZALEZ

INES FUENTES NORIEGA

DAVID MORALES MORALES

JUAN MANUEL GERMAN ACACIO

Access level

true

Open Access

Subjects

Summary or description

The reaction by melt mixing at 220 °C of the antihypergly-cemic drug metformin hydrochloride1with dehydrated sodium suc-cinate yields efficiently the organic salt [MET]2[SUC]2(H-MET+=metforminium and SUC2-= succinate). Solid state CPMAS NMR13Cspectroscopy experiments, powder X-ray diffraction and FT-IR re-sults support the formation of the pharmaceutical salt2in goodyields. Besides, thecharged-assisted hydrogen bonding interactionsof type N-H...-O(carboxylate) were thoroughly analyzed by singlecrystal X-Ray diffraction techniques. Thus, the pharmaceutical salt2possesses considerable thermal differences when compared to thepure starting reagents. In addition, intrinsic dissolution rate expe-riments in buffered aqueous solutions at pH= 6.8 showed a sus-tained-release behavior of the drug in2with a constant value ofKint= 0.885 mg/min * cm2.

Publisher

Sociedad Química de México

Publish date

2017

Publication type

Article

Format

application/application/pdf

Source

Journal of the Mexican Chemical Society (México) Num.3 Vol.61

Language

English

Relation

http://www.redalyc.org/revista.oa?id=475

Audience

Students

Researchers

Source repository

REPOSITORIO INSTITUCIONAL DE LA UAEM

Downloads

0

Comments



You need to sign in or sign up to comment.