Título
Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties
Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties
Autor
EDUARDO PLATA VARGAS
Cinthia Yareli De la Cruz Hernández
ALEJANDRO DORAZCO GONZALEZ
INES FUENTES NORIEGA
DAVID MORALES MORALES
JUAN MANUEL GERMAN ACACIO
Nivel de Acceso
true
Acceso Abierto
Materias
Química - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Diabetes - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Metformin - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) X-ray structures - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) ssCPMAS NMR13C - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Melting - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Succinate - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) mechanochemistry - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) green chemistry - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Química - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Diabetes - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Metformin - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) X-ray structures - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) ssCPMAS NMR13C - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Melting - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) Succinate - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) mechanochemistry - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) green chemistry - ([Journal of the Mexican Chemical Society (México) Num.3 Vol.61]) BIOLOGÍA Y QUÍMICA - (CTI)
Resumen o descripción
The reaction by melt mixing at 220 °C of the antihypergly-cemic drug metformin hydrochloride1with dehydrated sodium suc-cinate yields efficiently the organic salt [MET]2[SUC]2(H-MET+=metforminium and SUC2-= succinate). Solid state CPMAS NMR13Cspectroscopy experiments, powder X-ray diffraction and FT-IR re-sults support the formation of the pharmaceutical salt2in goodyields. Besides, thecharged-assisted hydrogen bonding interactionsof type N-H...-O(carboxylate) were thoroughly analyzed by singlecrystal X-Ray diffraction techniques. Thus, the pharmaceutical salt2possesses considerable thermal differences when compared to thepure starting reagents. In addition, intrinsic dissolution rate expe-riments in buffered aqueous solutions at pH= 6.8 showed a sus-tained-release behavior of the drug in2with a constant value ofKint= 0.885 mg/min * cm2.
Editor
Sociedad Química de México
Fecha de publicación
2017
Tipo de publicación
Artículo
Recurso de información
Formato
application/application/pdf
Fuente
Journal of the Mexican Chemical Society (México) Num.3 Vol.61
Idioma
Inglés
Relación
http://www.redalyc.org/revista.oa?id=475
Audiencia
Estudiantes
Investigadores
Repositorio Orígen
REPOSITORIO INSTITUCIONAL DE LA UAEM
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