Título
Organocatalytic cascade reaction for the synthesis of polycylic compounds utilizing Trienamine activation
Autor
SUHAS BALASAHEB MITKARI
Colaborador
David Cruz Cruz (Director)
CLARISA VILLEGAS GOMEZ (Director)
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
We report an Aminocatalytic privileged Diversity-Oriented Synthesis (ApDOS) strategy via trienamine catalysis for the construction of diverse and complex thiopyrans-piperidone fused rings through a thia-Diels–Alder/nucleophilic ring closing sequence by using dithioamides as activated heterodienophiles. Following this strategy, a super cascade reaction to assemble nine fused rings can be achieved by employing a bis-dithioamide. Additionally, by linking an indole moiety on the dithioamide, a Pictet-Spengler type reaction can be promoted once the cascade sequence has been achieved, leading to more complex penta- hexa- and heptacyclic fused ring derivatives in a one-pot process. This investigation, open new perspectives for the synthesis of a new class of complex and diverse thiopyrans, which contribute to populate new relevant regions in the chemical space.
Editor
Universidad de Guanajuato
Fecha de publicación
2021
Tipo de publicación
Tesis de doctorado
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Idioma
Inglés
Repositorio Orígen
Repositorio Institucional de la Universidad de Guanajuato
Descargas
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