Título
The content of gonadotropin-releasing hormone (GnRH), kisspeptin, and estrogen receptors (ERα/ERβ) in the anteromedial hypothalamus displays daily variations throughout the rat estrous cycle
Autor
ESTEBAN OLVERA JUAREZ
CARLOS CAMILO SILVA MENDEZ
ANGELICA FLORES FLORES
ISABEL ARRIETA CRUZ
LUCIANO MENDOZA GARCES
HILDA MARTINEZ CORIA
HECTOR EDUARDO LOPEZ VALDES
Luis Mario Cárdenas Camacho
ROBERTO DOMINGUEZ CASALA
ROGER GUTIERREZ JUAREZ
MARIA ESTHER CRUZ BELTRAN
Nivel de Acceso
Acceso Abierto
Materias
BIOLOGÍA Y QUÍMICA - (CTI) Biología celular - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Hormona liberadora de gonadotropina - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Gonadotropin-releasing hormone - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Receptor de estrógeno - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Estrogen receptor - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Kisspeptina - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Kisspeptin - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Ciclo estral - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Estrous cycle - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Asimetría hipotalámica - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)]) Hypothalamic asymmetry - ([Cell and Tissue Research (1432-0878) Vol. 381 (2020)])
Resumen o descripción
The content of gonadotropin-releasing hormone (GnRH), its mRNA, and estrogen receptor alpha (ERα) and beta (ERβ) in the hypothalamus varies throughout the estrous cycle. Furthermore, the abundance of these molecules displays asymmetry between the right and left side. In the present study, we investigated the changes in the content of ERα, ERβ, kisspeptin, and GnRH by western blot in the left and right anteromedial hypothalamus, at four different times during each stage of the rat estrous cycle. The serum levels of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were also measured. ERα and ERβ levels changed depending on the stage of the estrous cycle, meanwhile that of kisspeptin was modified according to both the hour of the day and the stage of the cycle. Except in estrus day, ERβ was higher in the right hypothalamus, while ERα was similar in both sides. During both proestrus and estrus, the content of kisspeptin and GnRH was higher in the right hypothalamus. The highest levels of FSH and LH occurred at 17:00 h of proestrus. But at estrus, the highest FSH levels were observed at 08:00 h and the lowest at 17:00 h. Thus, the current results show that the content of ERα, ERβ, kisspeptin, and GnRH in the anteromedial hypothalamus are regulated as a function of the stage of the estrous cycle and the hour of the day. Furthermore, the content of these proteins is regularly higher in the right anteromedial hypothalamus, regardless of the stage of the cycle or time of the day.
Editor
Springer
Fecha de publicación
2020
Tipo de publicación
Artículo
Recurso de información
Formato
Adobe PDF
application/pdf
Fuente
Cell and Tissue Research (1432-0878) Vol. 381 (2020)
Idioma
Inglés
Relación
https://link.springer.com/article/10.1007%2Fs00441-020-03258-x
Repositorio Orígen
INSTITUTO NACIONAL DE GERIATRIA
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