Título
Synthesis, characterization, and preliminary In vitro cytotoxic evaluation of a series of 2-substituted benzo [d] [1,3]
azoles
Autor
DAVID MORALES_MORALES
MARIA TERESA RAMIREZ
Alcives Avila-Sorrosa
Francisco Díaz
Jose Correa Basurto
Colaborador
Jorge Ali-Torres (Colaborador)
Domingo Salazar_Mendoza (Colaborador)
Nivel de Acceso
Acceso Abierto
Materias
BIOLOGÍA Y QUÍMICA - (CTI) 2-substituted benzo [d] [1,3] - ([Molecules (ISSN 1420-3049) 26, 2780]) azoles - ([Molecules (ISSN 1420-3049) 26, 2780]) In vitro cytotoxicity - ([Molecules (ISSN 1420-3049) 26, 2780]) Breast cancer - ([Molecules (ISSN 1420-3049) 26, 2780]) ERalpha and GPER - ([Molecules (ISSN 1420-3049) 26, 2780]) Molecular docking - ([Molecules (ISSN 1420-3049) 26, 2780])
Resumen o descripción
A series of benzo [d] [1,3] azoles 2-substituted with benzyl- and allyl-sulfanyl groups were synthesized, and their cytotoxic activities were in vitro evaluated against a panel of six human cancer cell lines. The results showed that compounds BTA-1 and BMZ-2 have the best inhibitory effects, compound BMZ-2 being comparable in some cases with the reference drug tamoxifen and exhibiting a low cytotoxic effect against healthy cells. In silico molecular coupling studies at the tamoxifen binding site of ERα and GPER receptors revealed affinity and the possible mode of interaction of both compounds BTA-1 and BMZ-2.
Fecha de publicación
2021
Tipo de publicación
Artículo
https://doi.org/10.3390/molecules26092780
Recurso de información
Formato
application/pdf
Fuente
Molecules (ISSN 1420-3049) 26, 2780
Idioma
Inglés
Relación
https://doi.org/10.3390/molecules26092780
Repositorio Orígen
Repositorio del Instituto de Química
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