Título

Production of plant secondary metabolites: Examples, tips and suggestions for biotechnologists

Autor

Gea Guerriero

Roberto Berni

JOSE ARMANDO MUÑOZ SANCHEZ

Fabio Apone

Eslam Abdel_Salam

Abdulhakim Qahtan

Abdulrahman A. Alatar

CLAUDIO CANTINI

Giampiero Cai

Jean-Francois Hausman

Khawar Siddiqui

SOLEDAD MARIA TERESA HERNANDEZ SOTOMAYOR

Mohammed Faisal

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Referencia de datos

datasetDOI/10.3390/genes9060309

Materias

SECONDARY METABOLITES - (AUTORES) ARTEMISIA - (AUTORES) ARTEMISININ - (AUTORES) URTICA DIOICA L. - (AUTORES) LIGNANS - (AUTORES) COFFEA ARABICA L. - (AUTORES) BIOLOGÍA Y QUÍMICA - (CTI) BIOLOGÍA Y QUÍMICA - (CTI)

Resumen o descripción

Plants are sessile organisms and, in order to defend themselves against exogenous (a)biotic constraints, they synthesize an array of secondary metabolites which have important physiological and ecological effects. Plant secondary metabolites can be classified into four major classes: terpenoids, phenolic compounds, alkaloids and sulphur-containing compounds. These phytochemicals can be antimicrobial, act as attractants/repellents, or as deterrents against herbivores. The synthesis of such a rich variety of phytochemicals is also observed in undifferentiated plant cells under laboratory conditions and can be further induced with elicitors or by feeding precursors. In this review, we discuss the recent literature on the production of representatives of three plant secondary metabolite classes: artemisinin (a sesquiterpene), lignans (phenolic compounds) and caffeine (an alkaloid). Their respective production in well-known plants, i.e., Artemisia, Coffea arabica L., as well as neglected species, like the fibre-producing plant Urtica dioica L., will be surveyed. The production of artemisinin and caffeine in heterologous hosts will also be discussed. Additionally, metabolic engineering strategies to increase the bioactivity and stability of plant secondary metabolites will be surveyed, by focusing on glycosyltransferases (GTs). We end our review by proposing strategies to enhance the production of plant secondary metabolites in cell cultures by inducing cell wall modifications with chemicals/drugs, or with altered concentrations of the micronutrient boron and the quasi-essential element silicon.

Fecha de publicación

2018

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Recurso de información

http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1553

Formato

application/pdf

Fuente

Genes, 9(6), 309, 2018.

Idioma

Inglés

Relación

&

Siddiqui, K. (2018). Production of plant secondary metabolites: Examples, tips and suggestions for biotechnologists. Genes, 9(6), 309.

Sugerencia de citación

Guerriero, G., Berni, R., Muñoz-Sanchez, J., Apone, F., Abdel-Salam, E., Qahtan, A., ...

Repositorio Orígen

Repositorio Institucional CICY

Descargas

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