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Filosofía de la física: vínculos entre teoría y observación desde la mecánica cuántica y la relatividad desde el descubrimiento del bosón de Higgs

PANIEL OSBERTO REYES CARDENAS (2016)

Paniel Reyes Cárdenas completó sus estudios de maestro en Filosofía y doctor en Filosofía (MPhil y PhD) en la Universidad de Sheffield, Reino Unido. Su tesis investigó el pragmatismo y la metafísica del realismo escolástico en C. S. Peirce. Aunque animado por su interés en la tradición pragmatista, Paniel tiene un amplio interés filosófico. Ha publicado artículos sobre Filosofía de las matemáticas, Metafísica, Filosofía medieval, Filosofía de la religión, Hegel, y sobre todo, Kierkegaard. Ha participado en un importante número de congresos académicos en más de 15 países y es fundador de la Sociedad Mexicana de Metafísica y Filosofía de la Ciencia. También es miembro activo del ChiPhi (Centre for the History of Philosophy) del consorcio de las universidades White Rose (Sheffield, Leeds y Yor de México. Después de hacer un postdoctorado en la Universidad de Nottingham (UK) Paniel se integró como profesor-investigador a la UPAEP, en donde es profesor ordinario de Filosofía del lenguaje y de Filosofía medieval.k) y miembro asociado de la Sociedad Académica Kierkegaard.

Universidad Iberoamericana Ciudad de México

Article

Filosofía de la física Mecánica cuántica Espacio-tiempo Modelo estándar de la física de partículas Philosophy of physics Quantum mechanics Space-time Standard model of particle physics HUMANIDADES Y CIENCIAS DE LA CONDUCTA

CYP450 Genotype/Phenotype Concordance in Mexican Amerindian Indigenous Populations–Where to from Here for Global Precision Medicine?

BLANCA PATRICIA LAZALDE RAMOS (2017)

Global precision medicine demands characterization of drug metabolism and phenotype variation in diverse populations, including the indigenous societies. A related question is the extent to which CYP450 drug metabolizing enzyme genotype and phenotype data are concordant and whether they can be used interchangeably. These issues are increasingly debated as precision medicine continues to expand as a popular research topic worldwide. We report here the first study in clinically relevant CYP450 drug metabolism phenotypes and genotypes in Mexican Amerindian indigenous subjects. In a large sample of 450 unrelated and medication free Mexican Amerindian indigenous healthy persons from four Mexican states (Chihuahua, Durango, Nayarit, and Sonora), we performed multiplexed phenotyping for the CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 drug metabolizing enzymes using the CEIBA cocktail and genotyped the same pathways for functional polymorphic variation. Remarkable interindividual variability was found for the actual drug metabolizing capacity of all the enzymes analyzed, and, more specifically, the metabolic ratios calculated were significantly different across individuals with different number of active alleles for CYP2C9, CYP2C19, and CYP2D6. The drug metabolizing capacity "predicted" from the genotype determined was not in accordance with the actual capacity "measured" by phenotyping in several individuals for CYP2C9, CYP2C19, and CYP2D6. Consequently, a more extensive genotyping of the main CYP enzymes, including rare variants, together with the analysis of the actual drug metabolizing capacity using an appropriate phenotyping approach will add valuable information for accurate drug metabolism studies, especially useful in understudied populations such as Mexican Amerindians. In sum, this study demonstrates that current personalized medicine strategies based on "predicted" phenotype from genotyping of alleles with high frequency in European populations are not adequate for Mestizos and Native American populations.

Producción Científica de la Universidad Autónoma de Zacatecas UAZ

Article

BIOLOGÍA Y QUÍMICA biomarkers developing world omics drug metabolism variation global personalized medicine systems diagnostics

Remedies for the Inconsistences in the Times of Execution of the Unsorted Database Search Algorithm within the Wave Approach

Remedies for the Inconsistences in the Times of Execution of the Unsorted Database Search Algorithm within the Wave Approach

Manuel Ávila Aoki José Benito Elizalde Salas (2017)

The typical semiclassical wave version of the unsorted database search algorithm based on a system of coupled simple harmonic oscillators does not consider an important ingredient of Grovers original algorithm as it is quantum entanglement. The role of entanglement in the wave version of the unsorted database search algorithm is explored and contradictions with the time of execution of Grovers algorithm are found. We remedy the contradictions by employing two arguments, one of them qualitative and the other quantitative. For the qualitative argument we employ the probabilistic nature of a legitimate quantum algorithm and remedy the above inconsistence. Within the quantitative argument we identify a parameter in the wave version of the unsorted database search algorithm which is related to entanglement. The contradiction with the time of execution of Grovers algorithm is solved by choosing an appropriate values of such a parameter which incorporates entanglement to the wave version of the unsorted database search algorithm. The utility of the present arguments are evident if the wave version of the unsorted data base search algorithm is experimentally implemented through a system of N quantum dots with a harmonic oscillator potential as a confinement potential for each of the quantum dots. Each of the above N vibrating quantum dots must be coupled to an extra single vibrating quantum dot which entangles to all of them. In order to obtain optimal results, the coupling constants of the mentioned quantum dots should be adjusted in the way described in the present work.

Article

Computación Unsorted database search Grover algorithm wave entanglement queries time Computación Unsorted database search Grover algorithm wave entanglement queries time INGENIERÍA Y TECNOLOGÍA

Reconfiguración incremental de sensores en la instrumentación de un calorímetro no-convencional

MARTHA CECILIA ARELLANO ALAMILLA (2020)

En la era de la tecnología, estamos observando cambios revolucionarios en nuestra manera de vivir, debido a la automatización de cualquier proceso, lo que nos vuelve cada vez más dependientes de la tecnología. Sin embargo, en la medida que incrementamos el uso de los dispositivos tecnológicos, mayoritariamente electrónicos, el problema de transferencia de calor crece de igual manera, además de ser este último un tema bastante desatendido. En este tenor, las necesidades mundiales de sistemas digitales complejos son cada día mayores, lo que da lugar a una excesiva generación de potencia térmica por efecto Joule. En últimas, contaminación. Por esta razón, es importante el desarrollo de sistemas contables con el objeto de cuantificar el impacto de este efecto térmico en nuestros dispositivos electrónicos y en el ambiente. En este trabajo de tesis se aborda el problema de instrumentación de un calorímetro no-convencional con el objetivo de mejorar su sensibilidad y, a su vez, la precisión en la medición de sus sensores. Las modificaciones propuestas permiten tener una mejor medición en la determinación experimental del flujo de calor generado por circuitos electrónicos. Las estrategias más importantes desarrolladas comprenden el ajuste de posición e incremento de sensores de manera experimental. Simultáneamente, se revisa y mejora el modelo matemático, con base en herramientas del cálculo fraccionario, utilizando resultados experimentales.

In the era of technology, we are observing revolutionary changes in daily life due to the automatization of any process, and we are becoming dependent on technology. However, as we increase the use of technology, the problem of heat transfer in electronic devices also grows besides being a subject very neglected. In such a tier, the world requirements of complex digital systems have been increased each day, generating heat substantially by the Joule effect. Namely, pollution. Therefore, it is crucial to develop reliable systems

to quantify the impact of the thermal effect on electronic devices. In this thesis, the instrumentation problem of a non-conventional calorimeter is addressed to increase the sensitivity and, simultaneously, the sensors’ precision. The proposed modification allows enhancing measurements in the experimental determination of heat dissipated by electronic circuits. Essential strategies are considered for rearranging and increasing heat sensors in the experimental setup. Simultaneously, a mathematical model is developed by using foundations from fractional calculus to improve the forecast of experimental results.

Master thesis

CIS- Maestría en Ingeniería Eléctrica (Instrumentación y Sistemas Digitales) INGENIERÍA Y TECNOLOGÍA CIENCIAS TECNOLÓGICAS TECNOLOGÍA DE LA INSTRUMENTACIÓN Calorímetro no-convencional – Instrumentación Sensores – Reconfiguración incremental Sistemas digitales Circuitos electrónicos – Generación de calor Non-conventional calorimeter – Instrumentation Sensors - Incremental reconfiguration Digital systems Electronic circuits - Heat generation

Perfect transfer of path-entangled photons in Jx photonic lattices

Héctor Manuel Moya Cessa (2013)

We demonstrate that perfect transfer of path-entangled photons as well as of single-photon states is possible in a certain class of spin inspired optical systems—the so-called Jx photonic lattices. In these fully integrable optical arrangements, perfect cyclic transitions from correlated states to totally anticorrelated states can naturally occur. Moreover we show that the bunching and antibunching response of path-entangled photons can be preengineered at will in such coupled optical arrangements. We elucidate these effects via pertinent examples.

Article

Photonic lattices Photons Optical systems CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA FÍSICA ÓPTICA ÓPTICA