Author: ALEJANDRO DORAZCO GONZALEZ

Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

EDUARDO PLATA VARGAS Cinthia Yareli De la Cruz Hernández ALEJANDRO DORAZCO GONZALEZ INES FUENTES NORIEGA DAVID MORALES MORALES JUAN MANUEL GERMAN ACACIO (2017)

The reaction by melt mixing at 220 °C of the antihypergly-cemic drug metformin hydrochloride1with dehydrated sodium suc-cinate yields efficiently the organic salt [MET]2[SUC]2(H-MET+=metforminium and SUC2-= succinate). Solid state CPMAS NMR13Cspectroscopy experiments, powder X-ray diffraction and FT-IR re-sults support the formation of the pharmaceutical salt2in goodyields. Besides, thecharged-assisted hydrogen bonding interactionsof type N-H...-O(carboxylate) were thoroughly analyzed by singlecrystal X-Ray diffraction techniques. Thus, the pharmaceutical salt2possesses considerable thermal differences when compared to thepure starting reagents. In addition, intrinsic dissolution rate expe-riments in buffered aqueous solutions at pH= 6.8 showed a sus-tained-release behavior of the drug in2with a constant value ofKint= 0.885 mg/min * cm2.

Article

Química Diabetes Metformin X-ray structures ssCPMAS NMR13C Melting Succinate mechanochemistry green chemistry Química Diabetes Metformin X-ray structures ssCPMAS NMR13C Melting Succinate mechanochemistry green chemistry BIOLOGÍA Y QUÍMICA

Structure of a Luminescent MOF-2 Derivative with a Core of Zn(II)-Terephthalate-Isoquinoline and Its Application in Sensing of Xylenes

Víctor Sánchez Mendieta Luis David Rosales Vázquez IVAN JONATHAN BAZANY RODRIGUEZ SIMON HERNANDEZ ORTEGA ALFREDO RAFAEL VILCHIS NESTOR JOSE DE JESUS CAZARES MARINERO ALEJANDRO DORAZCO GONZALEZ (2020)

Articulo de investigación publicado en revista indexada.

A new blue photoluminescent 2D metal–organic framework, 1, with formula {[Zn2( 2-BDC)2 (iQ)2]}1 has been synthesized in a high yield under solvothermal conditions by reacting Zn(II) ions with 1,4-benzenedicarboxylic acid (H2BDC) and isoquinoline (iQ) in DMF. Compound 1 was thoroughly characterized by single-crystal X-ray di raction, solid-state cross-polarization magic-angle spinning 13C NMR, X-ray powder di raction, scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS), and thermoanalysis. The crystal structure of 1 showed interpenetrated 2D frameworks consisting of dinuclear paddle-wheel cores Zn2; moreover, this material possessed thermostability up to 310 C. The CPMAS 13C-NMR spectrum of 1 is consistent with the symmetry of the crystal structure. Luminescence studies showed that 1 strongly enhances its fluorescence emission in the presence of xylene isomers with a pronounced selectivity to p-xylene.

Universidad Autónoma del Estado de México (Project 4995/2020CIB)

Article

xylene isomers fluorescent sensing MOF-2 derivative BIOLOGÍA Y QUÍMICA