Title

Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice

Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice

Author

ANABELLA MARTINEZ DOMINGUEZ

IRAZU CONTRERAS YANEZ

JOSE ANTONIO ESTRADA GUADARRAMA

Access level

true

Open Access

Summary or description

Oxidative stress (OS) is considered a risk factor for neurodegenerative disorders. Iron concentrations have been related to OS; however, the effect of iron deficiency (ID) on the induction of OS in the central nervous system (CNS) is unknown. A murine model of chronic diet-induced ID using 2 month-old male BALB/c mice (6 specimen), was used to determine its role in OS induction. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive species (TBARS) in the CNS, using the spleen for comparison. A decrease of peroxidation products in the CNS of the ID group (ID CNS), compared to controls fed on a regular diet, was found. The spleen showed a significant increase of lipid peroxidation in the ID group. Our results suggest that chronic ID may have differential effects on OS in the CNS and peripheral tissues. A decreased amount of reactive oxygen species in the basal state may be related to alterations on normal CNS metabolism and functions under chronic ID.

Publisher

Universidad de Guanajuato

Publish date

2017

Publication type

Article

Format

application/application/pdf

Source

Acta Universitaria (México) Num.6 Vol.27

Language

English

Relation

http://www.redalyc.org/revista.oa?id=416

Audience

Students

Researchers

Source repository

REPOSITORIO INSTITUCIONAL DE LA UAEM

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0

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