Título

Effect of n-3 polyunsaturated fatty acid supplementation on metabolic and inflammatory biomarkers in type 2 diabetes mellitus patients

Autor

MARIA GORETY JACOBO CEJUDO

ROSA VIRGEN PARDO MORALES

BEATRIZ ELINA MARTINEZ CARRILLO

LAURENCE S. HARBIGE

ROXANA VALDES RAMOS

ANA LAURA GUADARRAMA LOPEZ

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by/4.0

Materias

diabetes mellitus tipo 2 - ([20726643]) adipocinas - ([20726643]) perfil de lípidos - ([20726643]) n-3 PUFA - ([20726643]) MEDICINA Y CIENCIAS DE LA SALUD - (CTI)

Resumen o descripción

Artículo derivado de un proyecto de investigación de Suplementación con ácidos grasos poliinsaturados n-3 y vitamina D en pacientes con diabetes mellitus tipo 2

Abstract: Background: Type 2 diabetes mellitus (T2DM) is accompanied by chronic low-grade inflammation, with an imbalance in the secretion of adipokines and, worsening insulin resistance. Supplementation with n-3 PUFA in T2DM decreases inflammatory markers, the purpose of the study was to investigate the effect of n-3 PUFA supplementation on adipokines, metabolic control, and lipid profile in T2DM Mexican adults. Methods: In a randomized, single-blind, placebo-controlled pilot study, 54 patients with T2DM received 520 mg of DHA + EPA-enriched fish-oil (FOG) or a placebo (PG) daily. Baseline and 24-week anthropometric and biochemical measurements included glucose, insulin, glycosylated hemoglobin (Hb1Ac), leptin, adiponectin, resistin, and lipid profile; n-3 PUFA intake was calculated in g/day. Results: Waist circumference and blood glucose showed significant reductions in the FOG group (p = 0.001 and p = 0.011, respectively). Hb1Ac (p = 0.009 and p = 0.004), leptin (p < 0.000 and p < 0.000), and leptin/adiponectin ratio (p < 0.000 and p < 0.000) decreased significantly in both groups after 24 weeks (FOG and PG respectively). Serum resistin (FOG p < 0.000 and PG p = 0.001), insulin (FOG p < 0.000 and PG p < 0.000), and HOMA-IR (FOG p = 0.000 and PG p < 0.000) increased significantly in both groups. FOG had an overall improvement in the lipid profile with a significant decrease in triacylgycerols (p = 0.002) and atherogenic index (p = 0.031); in contrast, the PG group had increased total cholesterol (p < 0.000), non-HDL cholesterol (p < 0.000), and atherogenic index (p = 0.017). Conclusions: We found a beneficial effect of n-3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.

CONACyT, Desarrollo Científico para atender problemas nacionales, No. 212946

Editor

Nutrients

Fecha de publicación

3 de junio de 2017

Tipo de publicación

Artículo

Recurso de información

http://hdl.handle.net/20.500.11799/71028

Fuente

20726643

Idioma

Inglés

Audiencia

Estudiantes

Investigadores

Repositorio Orígen

REPOSITORIO INSTITUCIONAL DE LA UAEM

Descargas

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