Título
Iron profile and hepcidin associated with oxidative stress and metabolic disturbances in pregnancy
Autor
Karla Mariana Ortega López
ARACELI AMAYA CHAVEZ
ARACELI AMAYA CHAVEZ
Patricia Vieyra Reyes
Hugo Mendieta Zerón
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
Background: A common problem during pregnancy is anemia and to reduce its prevalence the WHO and national guidelines recommend a prescription of 30 to 60 mg of iron/day. The aim of this study was to evaluate the association of iron profile, hepcidin and oxidative stress in pregnant women prescribed with iron as a probable cause of metabolic disorders. Method: In this cohort study two groups were followed: A) women with low-risk pregnancy (WLRP), B) women with high-risk pregnancy (WHRP): women with metabolic disorders (dyslipidemias, GDM and high blood pressure). Oxidative stress enzymes, iron profile and hepcidin were measured in the second and third trimesters. Results: There were significant differences in hepcidin levels between WLRP and WHRP in 2nd (3.6 ± 4.2 vs 4.69 ± 3.23 P=0.005) and 3rd trimester (3.65 ± 3.44 vs 6.84 ± 5.14 P=0.02). The serum iron concentration had a negative relationship with catalase (-0.599; P=0.04) and a positive relationship with glutathione peroxidase (0.729; P=0.007). Conclusion: The iron serum levels increase could induce oxidative damage in pregnancy. Increased hepcidin is a useful biomarker for determining iron availability in pregnancy and its association with antioxidant systems.
Editor
Institute of Medico-Legal Publications
Fecha de publicación
25 de octubre de 2020
Tipo de publicación
Artículo
Recurso de información
Fuente
0976-5506
Idioma
Inglés
Relación
11
11
Audiencia
Estudiantes
Investigadores
Repositorio Orígen
REPOSITORIO INSTITUCIONAL DE LA UAEM
Descargas
65