Title
Iron profile and hepcidin associated with oxidative stress and metabolic disturbances in pregnancy
Author
Karla Mariana Ortega López
ARACELI AMAYA CHAVEZ
ARACELI AMAYA CHAVEZ
Patricia Vieyra Reyes
Hugo Mendieta Zerón
Access level
Open Access
Subjects
Summary or description
Background: A common problem during pregnancy is anemia and to reduce its prevalence the WHO and national guidelines recommend a prescription of 30 to 60 mg of iron/day. The aim of this study was to evaluate the association of iron profile, hepcidin and oxidative stress in pregnant women prescribed with iron as a probable cause of metabolic disorders. Method: In this cohort study two groups were followed: A) women with low-risk pregnancy (WLRP), B) women with high-risk pregnancy (WHRP): women with metabolic disorders (dyslipidemias, GDM and high blood pressure). Oxidative stress enzymes, iron profile and hepcidin were measured in the second and third trimesters. Results: There were significant differences in hepcidin levels between WLRP and WHRP in 2nd (3.6 ± 4.2 vs 4.69 ± 3.23 P=0.005) and 3rd trimester (3.65 ± 3.44 vs 6.84 ± 5.14 P=0.02). The serum iron concentration had a negative relationship with catalase (-0.599; P=0.04) and a positive relationship with glutathione peroxidase (0.729; P=0.007). Conclusion: The iron serum levels increase could induce oxidative damage in pregnancy. Increased hepcidin is a useful biomarker for determining iron availability in pregnancy and its association with antioxidant systems.
Publisher
Institute of Medico-Legal Publications
Publish date
October 25, 2020
Publication type
Article
Information Resource
Source
0976-5506
Language
English
Relation
11
11
Audience
Students
Researchers
Source repository
REPOSITORIO INSTITUCIONAL DE LA UAEM
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