Título
Intracellular signaling pathways involved in childhood acute lymphoblastic leukemia; molecular targets
Autor
CRISTIAN FABIAN LAYTON TOVAR
Hugo Mendieta Zerón
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
Acute lymphoblastic leukemia (ALL) is a malignant disease characterized by an uncontrolled proliferation of immature lymphoid cells. ALL is the most common hematologic malignancy in early childhood, and it reaches peak incidence between the ages of 2 and 3 years. The prognosis of ALL is associated with aberrant gene expression, in addition to the presence of numerical or structural chromosomal alterations, age, race, and immunophenotype. The Relapse rate with regard to pharmacological treatment rises in childhood; thus, the expression of biomarkers associated with the activation of cell signaling pathways is crucial to establish the disease prognosis. Intracellular pathways involved in ALL are diverse, including Janus kinase/Signal transducers and transcription activators (JAK-STAT), Phosphoinositide-3- kinase–protein kinase B (PI3K-AKT), Ras mitogen-activated protein kinase (Ras-MAPK), Glycogen synthase kinase-3b (GSK-3b), Nuclear factor-kappa beta (NF-jB), and Hypoxia-inducible transcription factor 1a (HIF-1a), among others. In this review, we present several therapeutic targets, intracellular pathways, and molecular markers that are being studied extensively at present.
Editor
Indian Journal of Hematology and Blood Transfusion
Fecha de publicación
junio de 2016
Tipo de publicación
Artículo
Recurso de información
Fuente
0971-4502
Idioma
Inglés
Relación
32
2
Audiencia
Estudiantes
Investigadores
Repositorio Orígen
REPOSITORIO INSTITUCIONAL DE LA UAEM
Descargas
45