Título
NF-κΒ and SOD expression in preeclamptic placentas
Autor
ABRAHAM SILVA CARMONA
Hugo Mendieta Zerón
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
Background/aim: Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-κΒ) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background. Materials and methods: Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-κΒ and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2–ΔΔct analysis method was used to measure the difference in the relative expression of the target genes in each group of patients. Results: In NF-κΒ expression, there was an increase of 23.35% in the group of women with preeclampsia versus women with preeclampsia without familial history. Regarding SOD, there was a reduction of about 33.33% in the expression in women with preeclampsia with familial history versus women with preeclampsia without familial history. Conclusion: Familial presence of preeclampsia could predispose to altered expression in SOD and NF-κΒ.
This project was partially funded by PROMEP/103.5/09/7342, Secretaría de Educación Pública, Mexico, and the Asociación Científica Latina (ASCILA).
Editor
Turkish Journal of Medical Sciences (TÜBİTAK)
Fecha de publicación
2016
Tipo de publicación
Artículo
Recurso de información
Fuente
1300-0144
Idioma
Inglés
Relación
46
3
Audiencia
Estudiantes
Investigadores
Repositorio Orígen
REPOSITORIO INSTITUCIONAL DE LA UAEM
Descargas
60