Título
Heart metabolic disturbances in cardiovascular diseases.
Autor
KARLA GUADALUPE CARVAJAL AGUILERA
RAFAEL MORENO SANCHEZ
Nivel de Acceso
Acceso Abierto
Materias
MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Adenosina Trifosfato metabolismo - ([Archives of Medical Research 34(2):89-99]) Cardiotónicos - ([Archives of Medical Research 34(2):89-99]) Enfermedades Cardiovasculares - Metabolismo - ([Archives of Medical Research 34(2):89-99]) Miocardio - Metabolismo - ([Archives of Medical Research 34(2):89-99]) Miocardio - Patología - ([Archives of Medical Research 34(2):89-99]) Oxigeno - Metabolismo - ([Archives of Medical Research 34(2):89-99]) Adenosine triphosphate - Metabolism - ([Archives of Medical Research 34(2):89-99]) Cardiotonic agents - ([Archives of Medical Research 34(2):89-99]) Cardiovascular diseases - Metabolism - ([Archives of Medical Research 34(2):89-99]) Myocardium - Metabolism - ([Archives of Medical Research 34(2):89-99]) Myocardium - Pathology - ([Archives of Medical Research 34(2):89-99]) Oxygen - Metabolism - ([Archives of Medical Research 34(2):89-99]) Metabolismo energético - ([Archives of Medical Research 34(2):89-99]) Metabolismo del corazón - ([Archives of Medical Research 34(2):89-99]) Glicolisis - ([Archives of Medical Research 34(2):89-99]) Fosforilación oxidativa - ([Archives of Medical Research 34(2):89-99]) Creatina quinasa - ([Archives of Medical Research 34(2):89-99]) L- carnitina - ([Archives of Medical Research 34(2):89-99]) Energy metabolism - ([Archives of Medical Research 34(2):89-99]) Heart metabolism - ([Archives of Medical Research 34(2):89-99]) Glycolysis - ([Archives of Medical Research 34(2):89-99]) Oxidative phosphorylation - ([Archives of Medical Research 34(2):89-99]) Creatine kinase - ([Archives of Medical Research 34(2):89-99]) L-carnitine - ([Archives of Medical Research 34(2):89-99])
Resumen o descripción
Myocardial function depends on adenosine triphosphate (ATP) supplied by oxidation of several substrates. In the adult heart, this energy is obtained primarily from fatty acid oxidation through oxidative phosphorylation. However, the energy source may change depending on several factors such as substrate availability, energy demands, oxygen supply, and metabolic condition of the individual. Surprisingly, the role of energy metabolism in development of cardiac diseases has not been extensively studied. For instance, alterations in glucose oxidation and transport developed in diabetic heart may compromise myocardial performance under conditions in which ATP provided by glycolysis is relevant, such as in ischemia and reperfusion. In some cardiac diseases such as ischemic cardiomyopathy, heart failure, hypertrophy, and dilated cardiomyopathy, ATP generation is diminished by derangement of fatty acid delivery to mitochondria and by alteration of certain key enzymes of energy metabolism. Shortage of some co-factors such as L-carnitine and creatine also leads to energy depletion. Creatine kinase system and other mitochondrial enzymes are also affected. Initial attempts to modulate cardiac energy metabolism by use of drugs or supplements as a therapeutic approach to heart disease are described
Editor
Instituto Mexicano del Seguro Social
Fecha de publicación
2003
Tipo de publicación
Artículo
Recurso de información
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3110
10.1016/S0188-4409(03)00004-3
Formato
application/pdf
Fuente
Archives of Medical Research 34(2):89-99
Idioma
Español
Repositorio Orígen
Repositorio del Instituto Nacional de Pediatría
Descargas
261