Título

Primary cultured astrocytes from old rats are capable to activate the Nrf2 response against MPP+ toxicity after tBHQ pretreatment

Autor

ADRIANA ALARCON AGUILAR

ARMANDO LUNA LOPEZ

JOSE LUIS VENTURA GALLEGOS

ROBERTO CARLOS LAZZARINI LECHUGA

SONIA GALVAN ARZATE

VIRIDIANA YAZMIN GONZALEZ PUERTOS

Julio Morán Andrade

ABEL SANTAMARIA DEL ANGEL

MINA KONIGSBERG FAINSTEIN

Nivel de Acceso

Acceso Abierto

Resumen o descripción

Astrocytes are key players for brain physiology, protecting neurons by releasing antioxidant enzymes; however, they are also susceptible to damage by neurotoxins. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a central regulator of the antioxidant response, and therefore, pharmacologic inducers are often used to activate this transcription factor to induce cellular protection. To date, it still remains unknown if cells from aged animals are capable of developing this response. Therefore, the purpose of this work was to determine if cortical astrocytes derived from old rats are able to respond to tertbuthyl-hydroquinene (tBHQ) pretreatment and stimulate the Nrf2-antioxidant response pathway to induce an antioxidant strategy against MPP+ toxicity, one of the most used molecules to model Parkinson's disease. Our results show that, although astrocytes from adult and old rats were more susceptible to MPP+ toxicity than astrocytes from newborn rats, when pretreated with tertbuthyl-hydroquinene, they were able to transactivate Nrf2, increasing antioxidant enzymes and developing cellular protection. These results are discussed in terms of the doses used to create protective responses.

Editor

Elsevier

Fecha de publicación

2014

Tipo de publicación

Artículo

Formato

Adobe PDF

application/pdf

Fuente

Neurobiology of Aging (0197-4580) Vol. 35 (2014)

Idioma

Inglés

Relación

https://www.sciencedirect.com/science/article/abs/pii/S0197458014001651?via%3Dihub

Repositorio Orígen

INSTITUTO NACIONAL DE GERIATRIA

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