Título
A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response
Autor
ARMANDO LUNA LOPEZ
VIRIDIANA YAZMIN GONZALEZ PUERTOS
Jacqueline Romero Ontiveros
JOSE LUIS VENTURA GALLEGOS
ALEJANDRO ZENTELLA DEHESA
LUIS ENRIQUE GOMEZ QUIROZ
MINA KONIGSBERG FAINSTEIN
Nivel de Acceso
Acceso Abierto
Materias
BIOLOGÍA Y QUÍMICA - (CTI) Ciencias de la vida - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Biología celular - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Químicos inorgánicos - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Radicales libres - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Estrés oxidativo - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Hormesis - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Respuesta adaptativa - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Cell biology - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Inorganic chemicals - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Free radicals - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Oxidative stress - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)]) Adaptative response - ([Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)])
Resumen o descripción
Cells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 μM H₂O₂ for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-κB. Interestingly, the noncanonical p50 subunit of the NF-κB family is apparently the subunit that participates during the oxidative-hormetic response.
Editor
Elsevier
Fecha de publicación
2013
Tipo de publicación
Artículo
Recurso de información
Formato
Adobe PDF
application/pdf
Fuente
Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)
Idioma
Inglés
Relación
https://www.sciencedirect.com/science/article/abs/pii/S0891584913001913?via%3Dihub#!
Repositorio Orígen
INSTITUTO NACIONAL DE GERIATRIA
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