Título

A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response

Autor

ARMANDO LUNA LOPEZ

VIRIDIANA YAZMIN GONZALEZ PUERTOS

Jacqueline Romero Ontiveros

JOSE LUIS VENTURA GALLEGOS

ALEJANDRO ZENTELLA DEHESA

LUIS ENRIQUE GOMEZ QUIROZ

MINA KONIGSBERG FAINSTEIN

Nivel de Acceso

Acceso Abierto

Resumen o descripción

Cells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 μM H₂O₂ for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-κB. Interestingly, the noncanonical p50 subunit of the NF-κB family is apparently the subunit that participates during the oxidative-hormetic response.

Editor

Elsevier

Fecha de publicación

2013

Tipo de publicación

Artículo

Formato

Adobe PDF

application/pdf

Fuente

Free Radical Biology and Medicine (0891-5849) Vol. 63 (2013)

Idioma

Inglés

Relación

https://www.sciencedirect.com/science/article/abs/pii/S0891584913001913?via%3Dihub#!

Repositorio Orígen

INSTITUTO NACIONAL DE GERIATRIA

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