Título
Long-Term Moderate Exercise Combined with Metformin Treatment Induces an Hormetic Response That Prevents Strength and Muscle Mass Loss in Old Female Wistar Rats
Autor
DAVID HERNANDEZ ALVAREZ
BEATRIZ MENA MONTES
RAFAEL TOLEDO PEREZ
GIBRAN PEDRAZA VAZQUEZ
STEFANIE PAOLA LOPEZ CERVANTES
Alfredo Morales Salazar
Edith Hernández Cruz
ROBERTO CARLOS LAZZARINI LECHUGA
Roman Royer Vázquez Cárdenas
Silvia Vilchis DeLaRosa
PEDRO POSADAS RODRIGUEZ
ROBERTO SANTIN MARQUEZ
OSCAR ROSAS CARRASCO
ALEJANDRA IBAÑEZ CONTRERAS
ADRIANA ALARCON AGUILAR
NORMA EDITH LOPEZ DIAZ GUERRERO
ARMANDO LUNA LOPEZ
MINA KONIGSBERG FAINSTEIN
Nivel de Acceso
Acceso Abierto
Materias
MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Ciencias médicas - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Ciencias clínicas - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Geriatría - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Atrofia muscular - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Sarcopenia - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Envejecimiento - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Aging - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Ejercicio - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Exercise - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Longevidad - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)]) Longevity - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)])
Resumen o descripción
Sarcopenia is a syndrome characterized by a progressive and generalized skeletal muscle mass and strength loss, as well as a poor physical performance, which as strongly been associated with aging. Sedentary lifestyle in the elderly contributes to this condition; however, physical activity improves health, reducing morbidity and mortality. Recent studies have shown that metformin (MTF) can also prevent muscle damage promoting muscular performance. To date, there is great controversy if MTF treatment combined with exercise training improves or nullifies the benefits provided by physical activity. This study is aimed at evaluating the effect of long-term moderate exercise combined with MTF treatment on body composition, strength, redox state, and survival rate during the life of female Wistar rats. In this study, rats performed moderate exercise during 20 of their 24 months of life and were treated with MTF for one year or for 6 months, i.e., from 12 to 24 months old and 18 to 24 months old. The body composition (percentage of fat, bone, and lean mass) was determined using a dual-energy X-ray absorption scanner (DXA), and grip strength was determined using a dynamometer. Likewise, medial and tibial nerve somatosensory evoked potentials were evaluated and the redox state was measured by HPLC, calculating the GSH/GSSG ratio in the gastrocnemius muscle. Our results suggest- that the MTF administration, both in the sedentary and the exercise groups, might activate a mechanism that is directly related to the induction of the hormetic response through the redox state modulation. MTF treatment does not eliminate the beneficial effects of exercise throughout life, and although MTF does not increase muscle mass, it increases longevity.
Editor
Hindawi
Fecha de publicación
2019
Tipo de publicación
Artículo
Recurso de información
Formato
Adobe PDF
application/pdf
Fuente
Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2019 (2019)
Idioma
Inglés
Relación
https://www.hindawi.com/journals/omcl/2019/3428543/
Repositorio Orígen
INSTITUTO NACIONAL DE GERIATRIA
Descargas
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