Título

CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico

Autor

BLANCA PATRICIA LAZALDE RAMOS

Nivel de Acceso

Acceso Abierto

Resumen o descripción

Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian groups from northwestern Mexico and compared them with the frequencies in Mexican Mestizos. Materials & methods: A total of 508 Amerindians were studied. Genotyping of CYP2D6 5 and multiplication alleles was performed by long-range PCR, while CYP2D62,3,4,6,10,17,29,35,41 and copy number were evaluated by real-time PCR. Results: The most frequent alleles were CYP2D62 (0.05-0.28), CYP2D64 (0.003-0.21) and multiplications (0.043-0.107). CYP2D65,6, * 10 and41 were not observed in the majority of Amerindians, and CYP2D63,17,35 and29 were not detected. The poor metabolizer genotype (4/5) was lower (0.2%) in Amerindians than in Mestizos (5%); conversely, the ultrarapid metabolizer genotype was higher (12.6%) in indigenous groups than in Mestizos (7%). Conclusion: Our data show a lower frequency of CYP2D6 inactive alleles and a higher frequency of duplication/multiplication of CYP2D6 active alleles in indigenous populations that in Mestizos.

Producción Científica de la Universidad Autónoma de Zacatecas UAZ

Fecha de publicación

17 de febrero de 2014

Tipo de publicación

Artículo

Recurso de información

Formato

application/pdf

Idioma

Español

Audiencia

Público en general

Repositorio Orígen

Repositorio Institucional Caxcán

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