Title

Ultraviolet-A Light Induces Micronucleated Erythrocytes in Newborn Rats

Author

BLANCA PATRICIA LAZALDE RAMOS

Access level

Open Access

Summary or description

Background: Ultraviolet-A (UV-A) light induce DNA damage by

creating pyrimidine dimers, or indirectly affects DNA by the formation

of reactive oxygen species. The objective was to determine DNA

damage by micronucleus test in neonatal rats exposed to UV-A

light.

Methods: Rat neonates were exposed to light from a LED

lamp (control group), to UV-C light 254 nm (control group to

desquamation skin) or UV-A light 365 nm and in one group the

dams were supplemented with folic acid (FA), to determine micro

nucleated erythrocytes (MNE) and micro nucleated polychromatic

erythrocytes (MNPCE) in peripheral blood of offspring.

Results: All the rat neonates exposed to UV-C lamp showed

desquamation skin, while for UV-A lamp no desquamation was

observed, and there was MNE differences in all sampling times

(P<0.02) and for MNPCE in 9 min group (P=0.001). No differences

between the groups with and without FA were observed.

Conclusion: Increased MNE frequencies without apparent damage

to the skin could be induced with UV-A light exposure. Under these

conditions, FA no protected against UV-A light exposure. This study

shows a manner to quantify the genotoxic effects of UV-A light in

peripheral blood erythrocytes of rat neonates.

Producción Científica de la Universidad Autónoma de Zacatecas UAZ

Publish date

April 8, 2016

Publication type

Article

Format

application/pdf

Language

English

Audience

General public

Source repository

Repositorio Institucional Caxcán

Downloads

0

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