Título
Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development
Autor
MARGARITA DE LA LUZ MARTINEZ FIERRO
IDALIA GARZA VELOZ
JOSE MANUEL ORTIZ RODRIGUEZ
RODRIGO CASTAÑEDA MIRANDA
LUIS OCTAVIO SOLIS SANCHEZ
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
Purpose: To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development.
Methods: Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls (n = 18) using TaqMan low density array plates.
Results: A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f3p, 520c-3p, and 520d-3p, were differentially expressed between groups (P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE (P = 0.035) and WWD-Severe-PE(P = 0.007).
Conclusions: Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further.
Producción Científica de la Universidad Autónoma de Zacatecas UAZ
Fecha de publicación
1 de diciembre de 2017
Tipo de publicación
Artículo
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application/pdf
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Inglés
Audiencia
Público en general
Repositorio Orígen
Repositorio Institucional Caxcán
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