Title

Expansion of human hematopoietic stem cells for transplantation: trends and perspectives

Author

Hera Andrade Zaldívar

MARTHA LETICIA SANTOS MARTINEZ

Antonio de León Rodríguez

Access level

Open Access

Alternative identifier

doi: https://doi.org/10.1007/s10616-008-9144-1

Summary or description

"Umbilical cord blood transplantation is clinically limited by its low progenitor cell content. Ex vivo expansion has become an alternative to increase the cell dose available for transplants. Expansion has been evaluated in several ways such as static cultures combining growth factors or mimicking the natural microenvironment using co-culture systems. However, static cultures have a small volume capacity and therefore large-scale expansion has been addressed using bioreactors. These and other biotechnological approaches for the expansion of hematopoietic progenitors and their utility to study several aspects of hematopoietic stem cell biology are discussed here."

Publisher

Springer

Publish date

March, 2008

Publication type

Article

Publication version

Accepted Version

Format

application/pdf

Relation

&

De León Rodríguez, A. Cytotechnology (2008) 56: 151. https://doi.org/10.1007/s10616-008-9144-1

Citation suggestion

Andrade-Zaldívar, H., Santos, L.

Source repository

Repositorio IPICYT

Downloads

251

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