Título
OPTICAL COHERENCE TOMOGRAPHY AND NANOPARTICLES WITH CONCAVE SURFACES: FROM THE FOLLOWING OF NANOPARTICLES GROWTH KINETICS TO THEIR USE AS CONTRAST AGENT
Autor
Yenisey Ponce de Leon
Colaborador
Juan L Pichardo_Molina (Asesor de tesis)
NOE ALCALA OCHOA (Asesor de tesis)
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
"The Optical Coherence Tomography (OCT) technique is an imaging modality that performs tomographic images with high resolutions (1-15µm) and high depth penetration capacity (12mm). It uses NIR light and is called the optical analogous of ultrasound. Its potential is based on the fact that is able to imaging transparent and highly scattering tissue samples, deeper and with better resolution than other techniques. However, tissues are optically inhomogeneous and the resulting scattering limits resolution and imaging depth; mainly in non transparent media. During the last decade, nanoparticles (NPs) have had a great impact on applications in different areas; one of them in the biomedical field as contrast agents, markers, sensors, etc. Nevertheless, most of the time the syntheses are not ideal, since they do not present high yield production and monodispersivity. In order to get a good synthesis, an understanding of the process that governs the NP growth is needed.
In this thesis an analysis of the growth kinetics of concave nanocubes by means of the Optical Coherence Tomography (OCT) technique is reported. In order to corroborate the viability of the OCT technique, UV-Vis spectroscopy and dynamic light scattering (DLS) experiments were also carried out. The results of the three techniques are very similar, confirming that OCT is a feasible technique to follow the NP growth kinetics. Furthermore, OCT shows the advantage over the UV-Vis spectroscopy technique that OCT is able to detect low concentrations of NPs, making it able to follow the synthesis since the beginning; and the monitoring is not affected by small variations in concentration. Additionally, the combination of these techniques allows getting complementary information of the synthesis without the need of expensive and sophisticated equipment. Moreover, to our knowledge, this is the first time that OCT is used to follow the NP growth kinetics."
Fecha de publicación
julio de 2014
Tipo de publicación
Tesis de doctorado
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Idioma
Inglés
Cobertura
León, Guanajuato
Audiencia
Público en general
Sugerencia de citación
Ponce de León Villanueva, (2014). "Optical Coherence Tomography and Nanoparticles with Concave Surfaces: From the following of nanoparticles growth kinetics to their use as contrast agent". Tesis de Doctorado en Ciencias (Óptica). Centro de Investigaciones en Óptica, A.C. León, Guanajuato. 90 pp.
Repositorio Orígen
REPOSITORIO INSTITUCIONAL DEL CIO
Descargas
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