Título
Modification of Ceiba pentandra cellulose for drug release applications
Autor
SILVIA ARGELIA PERAZA KU
JOSE MANUEL CERVANTES UC
Beatriz Escobar Morales
Jorge Alonso Uribe Calderón
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: 10.1515/epoly-2020-0025
Referencia de datos
datasetDOI/10.1515/epoly-2020-0025
Materias
Resumen o descripción
Tubular fibers (raw and wax-free) from Ceiba pentandra (CP) were cross-linked with butane-1,2,3,4-tetracarboxylic acid (BTCA) at different concentrations to obtain a porous biodegradable medium for drug release applications. Chlorhexidine diacetate (CHX) was added to the cross-linked fibers for drug release studies. The Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy results indicated that the cross-linked fibers with a 5:1 fiber:BTCA ratio presented the higher cross-linking density. CHX was added at different concentrations (8% and 16% wt/wt); the elemental analysis indicated that CHX was loaded up to 7.99 wt%. In vitro studies showed a burst release of CHX within the first 3 h. CHX release kinetics was described using several models, with the Korsmeyer–Peppas equation, which adjusted better to the experimental data. The results indicated that the CP fibers are a feasible material for drug release applications.
Fecha de publicación
2020
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
e-Polymers, 20(1), 194-202, 2020
Idioma
Inglés
Relación
&
Uribe-Calderon, J. A. (2020). Modification of Ceiba pentandra cellulose for drug release applications. e-Polymers, 20(1), 194-202.
Sugerencia de citación
Peraza-Ku, S. A., Cervantes-Uc, J. M., Escobar-Morales, B.,
Repositorio Orígen
Repositorio Institucional CICY
Descargas
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