Título

Apoptosis activation in human lung cancer cell lines by a novel synthetic peptide derived from Conus californicus venom

Autor

IRASEMA OROZ PARRA

Colaborador

Mario Navarro (Colaborador)

KARLA EVELIA CERVANTES LUEVANO (Colaborador)

CAROLINA ALVAREZ DELGADO (Colaborador)

Guy Salvesen (Colaborador)

LILIANA NOEMI SANCHEZ CAMPOS (Colaborador)

ALEXEI FEDOROVISH LICEA NAVARRO (Colaborador)

Nivel de Acceso

Acceso Abierto

Identificador alterno

doi: http://dx.doi.org/10.3390/toxins8020038

Resumen o descripción

"Lung cancer is one of the most common types of cancer in men and women and a leading cause of death worldwide resulting in more than one million deaths per year. The venom of marine snails Conus contains up to 200 pharmacologically active compounds that target several receptors in the cell membrane. Due to their diversity and specific binding properties, Conus toxins hold great potential as source of new drugs against cancer. We analyzed the cytotoxic effect of a 17-amino acid synthetic peptide (s-cal14.1a) that is based on a native toxin (cal14.1a) isolated from the sea snail Conus californicus. Cytotoxicity studies in four lung cancer cell lines were complemented with measurement of gene expression of apoptosis-related proteins Bcl-2, BAX and the pro-survival proteins NFκB-1 and COX-2, as well as quantification of caspase activity. Our results showed that H1299 and H1437 cell lines treated with s-call4.1a had decreased cell viability, activated caspases, and reduced expression of the pro-survival protein NFκB-1. To our knowledge, this is the first report describing activation of apoptosis in human lung cancer cell lines by s-cal14.1a and we offer insight into the possible mechanism of action."

Editor

MDPI AG

Fecha de publicación

2016

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Formato

application/pdf

Fuente

Toxins, Vol. 8, No. 2, Págs. 1-16

Idioma

Inglés

Sugerencia de citación

Oroz Parra,I.,Navarro,M.,Cervantes Luevano,K.E.,Álvarez Delgado,C.,Salvesen,G.,Sánchez Campos,L.N.,Licea Navarro,A.F.2016.Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom.Toxins,8(2),1-16.doi:10.3390/toxins8020038

Repositorio Orígen

Repositorio Institucional CICESE

Descargas

341

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