Advanced search


Knowledge area




37 results, page 1 of 4

El factor von Willebrand como biomarcador de riesgo trombótico por daño endotelial en infección por sars-cov-2 o cáncer de pulmón

Kenia Iraí Blancas Ayala (2021)

Facultad de Ciencias Médicas y Biológicas. Maestría en Ciencias de la Salud

Background: Thrombotic risk increases in patients with respiratory diseases such as lung cancer and SARS-Cov-2 infection, due to endothelial dysfunction that develops due to the activation of thrombotic and inflammatory processes. The von Willebrand Factor maintains hemostatic interactions, in addition; it is a biomarker of endothelial dysfunction, vascular damage causes the release of VWF from the Weibel-Palade bodies, the increase in its plasma concentration is related to thrombotic risk. The development of inflammatory processes accompanied by the mechanisms of evasion to the immune response of these respiratory pathologies, directly to the constitutive release of high molecular weight structures of VWF; as well as the increase in plasma concentrations and the decrease of its regulatory enzyme ADAMTS-13 favor a procoagulant state that maintains feedback cascades causing hemodynamic alterations until they become pathological. Objective: To establish the usefulness of plasma concentrations of VWF protein and ADAMTS 13 enzyme as biomarkers of thrombotic risk in lung cancer and SARS-CoV-2 infection. Materials and methods: Patients with lung cancer, patients with SARS-CoV-2 (COVID-19) infection and healthy subjects. Determination of plasma concentration of VWF and ADAMTS-13 by means of enzyme-linked immunoassay (ELISA) and analysis of multimeric structure by Western blot technique. Results: A total of 49 patients were included, distributed as follows; lung cancer patients (n = 8), COVID-19 patients (n = 25), healthy subjects (n = 16). Obtaining an average age of 52 years and where 61.2% belong to the male gender and 38.8% to the female gender. An increase in plasma VWF concentrations was observed in the group with lung cancer (p = 0.002) and the group with COVID-19 (p = 0.000) compared to the control group, as well as an increase in the densitometric mean of (p = 0.006) and (p = 0.001) respectively.

Antecedentes: El riesgo trombótico aumenta en los pacientes con enfermedades respiratorias como cáncer pulmonar e infección por SARS-Cov-2, debido a la disfunción endotelial que se desarrolla por la activación de procesos trombóticos e inflamatorios. El Factor von Willebrand mantiene numerosas interacciones hemostáticas; además, es un biomarcador de disfunción endotelial, el daño vascular causa la liberación de FvW de los cuerpos de Weibel- Palade, el incremento en su concentración plasmática está relacionada con el riesgo trombótico. El desarrollo de procesos inflamatorios acompañados de los mecanismos de evasión a la respuesta inmune de estas patologías respiratorias, contribuyen directamente a la liberación constitutiva de estructuras de elevado peso molecular de FvW; así como el incremento en las concentraciones plasmáticas y la disminución de su enzima reguladora ADAMTS-13 favorecen un estado procoagulante que mantiene cascadas de retroalimentación provocando las alteraciones hemodinámicas hasta convertirlas en patológicas. Objetivo: Establecer la variación de las concentraciones plasmáticas de la proteína FvW y enzima ADAMTS 13 como biomarcadores de riesgo trombótico en Cáncer pulmonar e infección por SARS-CoV-2. Materiales y métodos: Pacientes con cáncer pulmonar, pacientes con infección por SARS-CoV-2 (COVID-19) y sujetos sanos. Determinación de la concentración plasmática de FvW y ADAMTS-13 por medio de inmunoensayo ligado a enzima (ELISA) y análisis de la estructura multimérica mediante técnica de Western blot. Resultados: Se incluyeron un total de 49 pacientes distribuidos de la siguiente manera; pacientes con cáncer de pulmón (n=8), pacientes con COVID-19 (n=25), sujetos sanos (n=16). Obteniendo una edad promedio de 52 años y donde el 61.2% pertenece al género masculino y un 38.8% al género femenino. Se observó un incremento en las concentraciones plasmáticas del FvW en el grupo con cáncer pulmonar (p=0.002) y grupo con COVID-19 (p=0.000) en comparación al grupo control, así como un incremento en la media densitométrica de (p=0.006) y (p=0.001) respectivamente.

Master thesis

MEDICINA Y CIENCIAS DE LA SALUD FCMB-R-M-2021-0413 ADAMTS-13 Endotelitis Eventos trombóticos Netosis

Reticularity and innovation in actors and stakeholders of health tourism: competitiveness case in Los Algodones, Baja California

Sonia Guadalupe Zermeño Tomas Cuevas-Contreras Isabel Zizaldra Hernández (2021)

The manuscript explores reticularity and innovation in the field of tourism. Recent studies in competitiveness processes suggest that interested organizations become networks, which encourage cooperation with the purpose of becoming strong and reaching goals together. In this context, the objective of this research is to analyze the reticulation of actors and stakeholders, which through collaboration between them allows innovation in the creation of new products and services, more efficient processes and systems of work, improvement in methods of organization, as well as the introduction of novel forms of marketing; all of the above, aimed at health tourism in the region of influence of Los Algodones, B. C. (LAL). The research consisted of a quantum-qualitative study, using the methodology of Social Network Analysis (ARS), applying semi-structured interviews to leading actors in the tourism activity of health. The results obtained show that the networks between actors and stakeholders are established in relationships of trust, respect and commitment to the development of tourism activity; These allow collaborative processes that generate innovation and influence human resource training and joint promotion strategies.

Article

Artículo

Collaboration networks social network analysis innovation health tourism Colaboración redes análisis de redes sociales innovación turismo de salud CIENCIAS SOCIALES CIENCIAS SOCIALES

Woody debris trapping phenomena evaluation in bridge piers: A Bayesian perspective

Luis Horacio Martínez Martínez DAVID JOAQUIN DELGADO HERNANDEZ DAVID DE LEON ESCOBEDO Jhonnatan Flores Gomora JUAN CARLOS ARTEAGA ARCOS (2017)

l artículo propone el uso de una red bayesiana y analiza sus ventajas y desventajas para realizar el diagnóstico y la propuesta de remediación en el caso de puentes sujetos a la acumulación de escombros de madera en la base de las pilas.

A flood occurs when water and other materials such as woody debris overflow dry areas. If there is infrastructure present, woody fragments could be transported downstream and eventually trapped, leading to increments in the hydrodynamic forces over, say, a bridge. Moreover, local scour can be developed in the structure piers. The purpose of this research is to investigate the bridge pier scour phenomena induced by woody debris from a probabilistic point of view. A Non Parametric Bayesian Belief Network comprising seven nodes has consequently been developed. They are: water level, Froude number, blockage amount, drag force, scour depth, damage and overturning. Through both Monte Carlo Simulation and data from a real structure, the nodes’ non parametric probability distributions have been established, an area that has, to date, received very little attention in the literature. By combining the variables under study, it was possible to determine their interaction and dependencies, showing that the depth of the approaching flow is correlated with two nodes: damage and overturning. The results are useful for bridge managers willing to rank investments in maintenance actions within the industry, and to develop optimal risk based strategies for efficiently employing the scarce resources used to that end.

Article

Bayesian Net Bridge Damage Pier Scour Model Non-parametric Overturning BIOLOGÍA Y QUÍMICA

Procesos territoriales, participación social y globalización. Construyendo el espacio en los terrenos del exlago de Texcoco

MARIBEL ESPINOSA CASTILLO (2008)

El presente ensayo analiza el proceso social que se dio en la construcción de un área característica al nororiente de la ciudad de México, los territorios de lo que fue el lado de Texcoco. Define la transformación de los terrenos del lago en un área urbana en dos etapas: una de formación y otra de consolidación. En el proceso de construcción del espacio de esta región destaca la participación de la población, quien con sus obras, deseos y aspiraciones dieron forma y vida a las colonias del Vaso de Texcoco; asimismo la presencia de la globalización es significativa ya que fue la que presionó el cambio de uso de suelo, el incremento de la actividad comercial, el mejoramiento de las comunicaciones y transportes, etc., lo cual condujo a su consolidación.

This essay analyzes the social process featured in the construction of a characteristic area northeast of Mexico City: the territories of was the Texcoco Lake. It defines in two phases the transformation oh the lands nearby the lake into an urban area: one phase of transformation; another of consolidation. During the process of construction of the space in this region the participation of the population stands out, whose works, desires and aspirations have shaped the neighborhoods nearby the basin of Texcoco. The presence of globalization is meaningful as well: it was what led to change the use of soil, to an increase of commercial activity, and to the improvement of communications and transportation, all of which led to the consolidation of the urban area.

Article

Urbanization--Mexico--Netzahualcóyotl. City planning--Citizen participation. Globalization--Social aspects--Mexico. Urbanización. Participación social. Globalización (Economía). HT384.M62 CIENCIAS SOCIALES SOCIOLOGÍA SOCIOLOGÍA DE LOS ASENTAMIENTOS HUMANOS SOCIOLOGÍA URBANA

AFTHERSHOCKS INT THE FIRST 32 HOURS FOLLOWING OAXACA EARTHQUAKE OF 29 NOVEMBER, 1978 DETERMINED FROM SISMEX NETWORK

Shri Krishna Singh (1978)

Se han localizado 15 réplicas (3.5 < M < 4.5) ocurridas durante las primeras 32 horas del temblor principal de Oaxaca a partir de los datos de Ia red SISMEX. El área estimada de estas réplicas corresponde al 60% del área estimada para las réplicas registradas en el campo del 1o. al 12 de diciembre de 1978

Article

Oaxaca Earthquake Sismex Network Oaxaca Earthquake Sismex Network Seismology concept8601 Seismology CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA CIENCIAS DE LA TIERRA Y DEL ESPACIO GEOFÍSICA SISMOLOGÍA Y PROSPECCIÓN SÍSMICA

Situation of the elderly as a user of the internet in relation to its primary social network with relatives and migrants in Quindío – Colombia

Lilia Inés López Cardozo Sandra Adriana Leal Larrarte Lucero Giraldo (2021)

This article is part of the reflections of the authors` results of the investigation called Internet and Personal Network for the elderly with migrant relatives held in Armenia-Quindío; it brings into the light the situation that the elderly faces in using the Internet as a way to communicate with their migrant relatives. The project identifies the changes in the communication between the elderly and his relatives that the Internet creates in terms of structural features, functions, and personal relationships. Theorists who accompanied the epistemological framework for the interpretation of the data collection were: Garay (2006), Cardenas and Mejia (2006), (Castells, 2009), Marc Prensky (2001), (Machado, 2000) and Tovar Villarraga (2009). The methodology used was; the etnográfico- qualitative study, semi-structured interview total of (100), the sampling and for the organization and interpretation of information came to the Grounded Theory of Strauss and Corbin (2002).

Article

Artículo

Internet personal network the elderly grounded theory red personal adulto mayor teoría fundamentada CIENCIAS SOCIALES CIENCIAS SOCIALES

Analisis comparativo de la competitividad de la producción bovina en corral en Tejupilco y Amatepec, México

JUVENCIO HERNANDEZ MARTINEZ ALFREDO REBOLLAR REBOLLAR SAMUEL REBOLLAR REBOLLAR EUGENIO GUZMAN SORIA GERMAN GOMEZ TENORIO (2020)

articulo cientifico

Se realizó un análisis comparativo de la competitividad de la producción bovina 12 engordada en corral en Tejupilco y Amatepec, Estado de México de 2009 a 2014. La 13 información se obtuvo de 40 productores. El cálculo de los indicadores de competitividad 14 y de rentabilidad se realizó a través de la Matriz de Análisis de Política (MAP).

Article

ganancia neta rentabilidad relación de costo privado CIENCIAS SOCIALES

The literature on open government in spanish. Analysis of the dynamics of production and citation

Diego Barria Traverso Bastián González_Bustamante Carla Cisternas (2021)

Open government has become one of the concepts that most recently attracted professionals and academics dedicated to public administration. Likewise, it is possible to notice the appearance of a growing volume of academic works dedicated to analyzing the concept and experiences of open government in the region. This paper analyzes the academic production in Spanish on open government. For this, texts published in specialized journals between 2009 and 2015 are identified. It characterizes the main publication channels, indexing levels of journals that publish articles of the topic as well as bibliographic references. This is complemented by a citation network analysis and a statistical model that evaluates determinants of centrality in the network. One of the findings is that non-academic documents are more likely to be central in the citation network.

Article

Artículo

Open government scientific production network analysis Latin America Gobierno abierto producción científica análisis de redes América Latina CIENCIAS SOCIALES CIENCIAS SOCIALES

A performance comparison of CMOS voltage-controlled ring oscillators for its application to generation and distribution clock networks

MONICO LINARES ARANDA OSCAR GONZÁLEZ DÍAZ Carlos Ramón Báez Álvarez (2013)

In this work, a performance comparison of expanded CMOS voltage-controlled ring oscillators for non-resonant local clock generation and distribution networks is presented. Several differential and single-ended ring oscillators are designed and fabricated using long interconnection lines to achieve wide coverage chip. A test chip containing the several oscillators was fabricated using an Austria Microsystems (AMS) 0.35 μm CMOS technology. Experimental results show that it is possible to generate and distribute high frequency signals (GHz range) on a relativity large area (coverage) and low phase noise using non-resonant ring oscillators. This represents an attractive alternative for the design and implementation of local Clock Generation and Distribution Networks for systems on chip.

Article

Ring Oscillators VCOs Clock Networks CMOS VLSI CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA FÍSICA ELECTRÓNICA ELECTRÓNICA