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Association of extrapituitary prolactin promoter polymorphism with disease susceptibility and anti-RNP antibodies in Mexican patients with systemic lupus erythematosus.

JORGE HERNANDEZ BELLO CLAUDIA AZUCENA PALAFOX SANCHEZ SAMUEL GARCIA ARELLANO ZYANYA REYES CASTILLO ANA LAURA PEREIRA SUAREZ ISELA PARRA ROJAS JOSE EDUARDO NAVARRO ZARZA ULISES DE LA CRUZ MOSSO NORA MAGDALENA TORRES CARRILLO Jose Francisco Muñoz Valle (2016)

Prolactin (PRL) is a 23-kDa protein that can be synthesized and secreted by pituitary and extrapituitary tissues such as immune cells due to its expression being regulated by two independent promoter regions. The promoter which is responsible for extrapituitary expression contains the single nucleotide polymorphism (SNP) ¿1149 G/T previously associated with autoimmune diseases in various populations. This study evaluates the relationship of PRL ¿1149 G/T polymorphism with PRL serum levels and clinical characteristics in systemic lupus erythematosus (SLE) patients from western Mexico.

Article

systemic lupus erythematosus prolactin, BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA OTRAS ESPECIALIDADES DE LA BIOLOGÍA

Perfect transfer of path-entangled photons in Jx photonic lattices

Héctor Manuel Moya Cessa (2013)

We demonstrate that perfect transfer of path-entangled photons as well as of single-photon states is possible in a certain class of spin inspired optical systems—the so-called Jx photonic lattices. In these fully integrable optical arrangements, perfect cyclic transitions from correlated states to totally anticorrelated states can naturally occur. Moreover we show that the bunching and antibunching response of path-entangled photons can be preengineered at will in such coupled optical arrangements. We elucidate these effects via pertinent examples.

Article

Photonic lattices Photons Optical systems CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA FÍSICA ÓPTICA ÓPTICA

CYP450 Genotype/Phenotype Concordance in Mexican Amerindian Indigenous Populations–Where to from Here for Global Precision Medicine?

BLANCA PATRICIA LAZALDE RAMOS (2017)

Global precision medicine demands characterization of drug metabolism and phenotype variation in diverse populations, including the indigenous societies. A related question is the extent to which CYP450 drug metabolizing enzyme genotype and phenotype data are concordant and whether they can be used interchangeably. These issues are increasingly debated as precision medicine continues to expand as a popular research topic worldwide. We report here the first study in clinically relevant CYP450 drug metabolism phenotypes and genotypes in Mexican Amerindian indigenous subjects. In a large sample of 450 unrelated and medication free Mexican Amerindian indigenous healthy persons from four Mexican states (Chihuahua, Durango, Nayarit, and Sonora), we performed multiplexed phenotyping for the CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 drug metabolizing enzymes using the CEIBA cocktail and genotyped the same pathways for functional polymorphic variation. Remarkable interindividual variability was found for the actual drug metabolizing capacity of all the enzymes analyzed, and, more specifically, the metabolic ratios calculated were significantly different across individuals with different number of active alleles for CYP2C9, CYP2C19, and CYP2D6. The drug metabolizing capacity "predicted" from the genotype determined was not in accordance with the actual capacity "measured" by phenotyping in several individuals for CYP2C9, CYP2C19, and CYP2D6. Consequently, a more extensive genotyping of the main CYP enzymes, including rare variants, together with the analysis of the actual drug metabolizing capacity using an appropriate phenotyping approach will add valuable information for accurate drug metabolism studies, especially useful in understudied populations such as Mexican Amerindians. In sum, this study demonstrates that current personalized medicine strategies based on "predicted" phenotype from genotyping of alleles with high frequency in European populations are not adequate for Mestizos and Native American populations.

Producción Científica de la Universidad Autónoma de Zacatecas UAZ

Article

BIOLOGÍA Y QUÍMICA biomarkers developing world omics drug metabolism variation global personalized medicine systems diagnostics

An experimental approach to discrete dynamical systems with Mathematica

Michael Studer (2021)

Experiment with discrete time dynamical systems, may represent an important educational resource in the investigation of the properties of dynamical systems and their potential applications to disciplines such as economics. As an illustration of this possibility teaching, this paper provides a brief introduction to the dynamics of discretetime dynamic systems using examples assisted by the symbolic language Mathematica. Such systems are essentially iterated maps. In the first part, we construct orbits of points under iteration of real and complex functions. If x is a real number or a complex number, then the orbit of x under f is the sequence {x, f (x), f (f (x)), ...}. These sequences may be convergent or sequences that tend to infinity. In particular, to test this behavior in complex sequences will require the concept of derivative of a complex function. In a second part, we use the concepts reviewed in the first to build Julia sets, these sets are obtained by assigning colors to a rectangular grid points according to the behavior of their orbits under the studied complex function, the colors are assigned according the classification of the points. The pattern obtained, the Julia set is a fractal. However, the image obtained is always an approximation.

Article

Artículo

Iteration dynamic system Mathematica fixed point orbits Julia set Iteración sistema dinámico punto fijo orbita conjunto Julia CIENCIAS SOCIALES CIENCIAS SOCIALES

Systemic resistance induction by plant growth promoting rhizobacteria (pgpr) in solanum tuberosum

EPIFANIO CASTRO DEL ANGEL FRANCISCO DANIEL HERNÁNDEZ CASTILLO ROBERTO ARREDONDO VALDES ESMERALDA GONZALEZ GALLEGOS YISA MARIA OCHOA FUENTES GABRIEL GALLEGOS MORALES (2017)

"Currently many studies have been made on the use of natural products as substitutes for chemical control, due to possible ecological and economic advantages that many of these compounds offer, especially in crop protection. Many natural products have compounds with the ability to stimulate defense mechanisms in plants; defense reactions to the nearest tissue infection are restricted in some cases, resistance induction is associated to the expression of some defense genes, such as those coding for proteins linked to the pathogenesis. For example phenylalanine ammonia lyase and synthesis phytoalexins are highly toxic compounds to the pathogen. On the other hand the increase of peroxidases, can increase the mechanical strength of the host cells walls, inhibiting or possibly restricting a pathogen invasion. The objective of this study was to compare the effect of the PGPR consortium at 6, 12 and 24 hours after application, against Fusarium oxysporum and Rhizoctonia solani, determined by leaf tissue, quantification of protein and enzyme activities of phenylalanine ammonia lyase and peroxidase. The results presented in this paper clearly demonstrated the potential of the PGPR consortium strains to activate resistance against F. oxysporum or R. solani."

Article

Bacillus spp Fusarium oxysporum Rhizoctonia solani Potato Systemic resistance CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA