Author: MIGUEL ANGEL ONTIVEROS TORRES

Effect of the inflammation on the aggregation of the tau and amyloid-β polypeptides in the pyramidal neurons on the hippocampus of a triple transgenic murine model for the Alzheimer’s disease

MIGUEL ANGEL ONTIVEROS TORRES (2020)

208552

Alzheimer’s Disease (AD) is the most important form of dementia. It represents 70% of all dementia cases worldwide. On a molecular level, AD is characterized by the presence of two fibrillar lesions: the neurofibrillary tangles (NFT) due to the oligomerization of pathological forms caused by post-translational modifications (PTMs) of protein Tau and; the aggregation of peptide amyloid-β (Aβ), product of a bad-processing of amyloid precursor protein (APP) forming neuritic plaques (NP). The triple transgenic mice (3xTg-AD) presents some pathological species of Tau and Aβ aggregations. 3xTg-AD mice received an ethanol treatment to evaluate the generation of proteolyzed forms of Tau through the induction of an exacerbated neurotoxic state Caspase 3 activity was observed accompanied by an increment of NPs in the hippocampus, as well as, the presence of neurofibrillary aggregations of Tau and Aβ.

Master of Science in Biotechnology

Master thesis

MEDICINA Y CIENCIAS DE LA SALUD CIENCIAS MÉDICAS PATOLOGÍA NEUROPATOLOGÍA