Author: JUAN MANUEL GERMAN ACACIO

Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties

EDUARDO PLATA VARGAS Cinthia Yareli De la Cruz Hernández ALEJANDRO DORAZCO GONZALEZ INES FUENTES NORIEGA DAVID MORALES MORALES JUAN MANUEL GERMAN ACACIO (2017)

The reaction by melt mixing at 220 °C of the antihypergly-cemic drug metformin hydrochloride1with dehydrated sodium suc-cinate yields efficiently the organic salt [MET]2[SUC]2(H-MET+=metforminium and SUC2-= succinate). Solid state CPMAS NMR13Cspectroscopy experiments, powder X-ray diffraction and FT-IR re-sults support the formation of the pharmaceutical salt2in goodyields. Besides, thecharged-assisted hydrogen bonding interactionsof type N-H...-O(carboxylate) were thoroughly analyzed by singlecrystal X-Ray diffraction techniques. Thus, the pharmaceutical salt2possesses considerable thermal differences when compared to thepure starting reagents. In addition, intrinsic dissolution rate expe-riments in buffered aqueous solutions at pH= 6.8 showed a sus-tained-release behavior of the drug in2with a constant value ofKint= 0.885 mg/min * cm2.

Article

Química Diabetes Metformin X-ray structures ssCPMAS NMR13C Melting Succinate mechanochemistry green chemistry Química Diabetes Metformin X-ray structures ssCPMAS NMR13C Melting Succinate mechanochemistry green chemistry BIOLOGÍA Y QUÍMICA