Author: JOSE DE JESUS GARDUÑO GARCIA
Objetivo. Establecer la correlación entre las concentraciones séricas de triyodotironina y la resistencia a la insulina a través del índice HOMA en un grupo de hombres adolescentes con factores de riesgo para el desarrollo de diabetes. Materiales y métodos: estudio descriptivo de corte transversal. Participaron adolescentes con algún factor de riesgo para diabetes. Se determinó la presencia de síndrome metabólico empleando los criterios de ATPIII modificada por Cook. Se determinaron T3, T4, TSH e insulina basal. Se calculó el índice HOMA para resistencia a la insulina. Resultados. Se estudiaron 36 hombres con una edad promedio de 15.97±0.9 años. En la población total existió correlación positiva entre T3 y HOMA-IR (r=0.380 p=0.022), cuando se analizó en el grupo de SM la correlación se incrementó entre T3 y HOMA-IR (r=0.647 p=0.031). Determinando que existe correlación positiva entre los índices de resistencia a la insulina y las concentraciones de hormona tiroidea.
The Obesity-associated fat mass (FTO) gene has been associated to a higher risk of obstetrical complications. The aim of this prospective, cross-sectional and comparative study was to determine if there are clinical or laboratorial differences in pregnant women with the presence/absence of FTO rs9939609 focused on threatened abortion. Pregnant women between 18 to 35 years of age were invited to participate. In all cases, it was obtained the sociodemographic information, anthropometry, clinical laboratories for obstetrical routine check-up, FTO rs9939609 positive expression, and the homeostasis model assessment (HOMA) and the quantitative insulin sensitivity check index (QUICKI) indexes were also calculated. Comparisons of this type of variables between both groups were performed through Student´s T-test. Chi-Square Tests were used to contrast the GDM and threatened miscarriages percentages of cases between both groups. Pearson correlation was performed among the quantitative variables of all the study population. 57 women positive and 52 negative for the FTO rs9939609 presence were included in the study with a Gestational Diabetes Mellitus prevalence of 19.3%. When contrasting the variables by the presence/absence of FTO rs9939609 the p-values were far from being significant. As such, Chi-Square Tests did not show significant statistical difference neither for GDM nor for threatened miscarriage between both groups. Based on these results, the FTO rs9939609 presence did not reflect difference either in GDM or in threatened miscarriage. It was demonstrated in parallel, the utility of the QUICKI index in the metabolic evaluation during pregnancy. In conclusion, in Mexican women, pregnancy evolution and possible appearance of complications is not so determined by the FTO rs9939609 presence but by the overweight with which this physiological state is faced.
JOSE DE JESUS GARDUÑO GARCIA ENEIDA DEL SOCORRO CAMARILLO ROMERO Ana Loe Ochoa MARIA DEL SOCORRO ROMERO FIGUEROA GABRIEL GERARDO HUITRON BRAVO ROCIO TORRES GARCIA Laura Patricia Montenegro Morales Hugo Mendieta Zerón (2015)
Introduction: The prevalence of obesity and Type 2 diabetes mellitus (T2DM) among children and adolescents is rising. Thyroid function has been associated with insulin resistance. There is scarce information about how thyroid function could be related with cardiovascular risk or glucose homeostasis in adolescent. Aim: To analyze how thyroid function is associated with insulin resistance and another cardiovascular risk factors in healthy adolescents with risk factors to develop diabetes. Methods: A prospective cross-sectional analysis was carried out on euthyroid, adolescents. considered at high risk to develop Type 2 diabetes. Fasting blood samples were obtained. Thyroid function test and another cardiometabolic parameters were assessed. A 75 grams oral glucose tolerance test was performed to calculate insulin resistance. Results: One hundred adolescents were evaluated. The mean age was 15.9 ± 0.8 years, There is a negative correlation between Fasting insulin, post glucose load insulin and HOMA IR. There were no correlation with Matsuda index. We could not found any correlation with TSH values. Conclusions: We found a correlation between fasting insulin, HOMA IR and serum thyroid hormones, we did not find any relation with serum TSH. In euthyroid adolescents with risk factors to develop diabetes.