Author: GABRIELA MARTINEZ AGUILAR

El Esquema Legal de Protección sui generis de los Conocimientos Tradicionales Asociados a la Medicina Tradicional en México

GABRIELA MARTINEZ AGUILAR NIMCY ARELLANES CANCINO (2019)

"En el artículo se analizan las aplicaciones del esquema de protección legal sui generis en propiedad intelectual de la medicina tradicional mexicana. La investigación es cualitativa, con aproximación a la investigación acción, y basada en una revisión exhaustiva de fuentes de archivos nacionales e internacionales. Se apunta que es viable la adaptación de las particularidades a una protección defensiva mediante la estrategia de bases de datos para evitar la apropiación ilegítima. Esto implica la identificación de categorías jurídicas suficientemente inclusivas de aquello que hay que proteger, ya sean atemporales o que reconozcan la variabilidad cultural. El trabajo contribuye a distinguir el derecho individual y el colectivo, así como a favorece la defensa de los recursos bióticos asociados a la medicina tradicional."

Article

Medicina folklórica Medicina popular Propiedad intelectual -- Leyes y legislación -- México HUMANIDADES Y CIENCIAS DE LA CONDUCTA ANTROPOLOGÍA ANTROPOLOGÍA

Anthelmintic activity of extracts and active compounds from Diospyros anisandra on Ancylostoma caninum, Haemonchus placei and Cyathostomins

GABRIELA JANETT FLOTA BURGOS José Alberto Rosado Aguilar ROGER IVAN RODRIGUEZ VIVAS ROCIO DE LOURDES BORGES ARGAEZ CINTLI MARTINEZ ORTIZ DE MONTELLANO MARIA MARCELA GAMBOA ANGULO (2020)

The present study aimed to evaluate the anthelmintic activity of leaf and bark extracts ofDiospyros anisandracollected during different seasons and their major constituents on eggs ofAncylostoma caninum, Haemonchus placei, and cyathostomins. Specifically, the eclosion inhibition of the methanolic extracts of the leaves and bark ofD. anisandracollected during the dry and rainy seasons (600-37.5 mu g/ml) were evaluated in addition to the fractions, sub-fractions (300-37.5 mu g/ml) and active major constituents (150-2.3 mu g/ml). The rainy season bark extract had the highest percentage of eclosion inhibition (PEI) against the evaluated nematodes (>= 90% at 75 mu g/ml) along with high ovicidal activity (90.0 to 93.4% at 75 mu g/ml). The purification of the rainy season bark extract showed that its biological activity came from the non-polarn-hexane fraction (>= 93% at 75 mu g/ml). The bioguided fractionation pointed to sub-fraction 5 as having the highest anthelmintic activity against the three evaluated genera of nematodes (PEI >= 93% at 37.5 mu g/ml). Gas chromatography and mass spectrometry revealed that the major constituent in sub-fraction 5 was plumbagin. Upon evaluation, plumbagin was confirmed to be responsible for the anthelmintic activity ofD. anisandra, with a PEI >= 90% at 2.3 mu g/ml on the three evaluated nematodes. Additionally, the compounds betulin and lupeol in the bark ofD. anisandrawere evaluated but presented low anthelmintic activity (PEI <= 5.3% at 2.3 mu g/ml). In conclusion, the rainy season bark extract ofD. anisandraexerts a high ovicidal activity against the eggs of the three studied nematodes. Plumbagin is the active compound responsible for this activity and represents a potential alternative for the control of different genera of gastrointestinal nematodes given the current scenario of anthelmintic resistance.

Article

ACTIVE COMPOUNDS BIOGUIDED FRACTIONATION GASTROINTESTINAL NEMATODES PLANT EXTRACTS PLUMBBAGIN BIOLOGÍA Y QUÍMICA QUÍMICA QUÍMICA ORGÁNICA BIOLOGÍA MOLECULAR BIOLOGÍA MOLECULAR